r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
r-Retinoate™ Ultimate Night
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r-Retinoate™ Ultimate Night

  • Rejuvenate
  • |
  • Firm
  • |
  • Brighten
Youth Awakening Cream

Setting new standards for age-defying excellence, r-Retinoate Ultimate Night is the jewel in the Medik8 Vitamin A crown. 

Proven to deliver noticeably firmer, smoother, brighter-looking skin, with dramatic wrinkle and dark spot reduction in as little as 4 weeks.*

Also proven to be 8x stronger** and 11x faster^ than classic retinol, this innovative vitamin A formula is powered by a revolutionary blend of retinal and encapsulated retinyl retinoate (exclusive to Medik8).

Combining 5 of Medik8's most advanced age-defying technologies in 1 extraordinary nighttime cream, r-Retinoate Ultimate Night delivers everything your skin needs for astonishing youth-renewing results in one simple but luxurious step.

*Proven via independent consumer study on r-Retinoate Intense on 52 participants over 4 weeks.
**H. Kim et al., Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative, Bioorganic & Medicinal Chemistry, 2008, 15;16(12), pp 6387-93
^G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378
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r-Retinoate™ Day & Night
r-Retinoate™ Day & Night
  • Brighten
  • |
  • Smooth
  • |
  • Revive
 Youth Awakening Cream
Full Size
Key Benefits
Astonishing Age-Defying Results

Proven to simultaneously improve the look of skin brightness, uneven tone and dark spots - even on sensitive skin.

5-in-1 Time Saver

Combines 5 of Medik8’s most advanced age-defying technologies for the fastest, most effective, all round age-defying results in one masterpiece formula.

8x Stronger & 11x Faster Than Retinol

Combines Medik8-exclusive encapsulated retinyl retinoate (8x more powerful than retinol*) with our patented crystal-stabilized retinal (11x faster than retinol**), for previously unattainable age-defying results.

*H. Kim et al., Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative, Bioorganic & Medicinal Chemistry, 2008, 15;16(12), pp 6387-93
**G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378

Simplifies Your Nighttime Regimen

Delivers your nighttime serum and cream in one, removing the need for multiple steps in your evening regimen.

Proven Results
7 days to visibly brighter more even-toned skin*
4 weeks to dramatic wrinkle reduction*
4 weeks to visibly reduced dark spots*
96% agree the all-in-one cream made their regimen simpler and shorter*
96% agree r-Retinoate Ultimate Night is non-irritating on the skin*
*Proven via independent consumer study on r-Retinoate Ultimate Night on 52 participants over 4 weeks.
How to Use

First-Time Use

If you're new to r-Retinoate Intense we recommend a patch test at least 24 hours before first use. Learn how to patch test here.

Phase application in gradually. Use twice a week for the first 2 weeks, every other night for the next 2 weeks, then every night.

Step 1

After cleansing in the evening, massage 2 pumps of r-Retinoate Ultimate Night evenly across face, neck and décolletage.

Step 2

Use a sunscreen every morning while using retinoids.

Uses per bottle

90
Guide to Layering
Step 1: Cleanse
Surface Radiance Cleanse
Morning
Evening
Surface Radiance Cleanse
Full Size (5.0 FL. OZ. (150 mL))
Step 2: Target
r-Retinoate™ Day & Night
Morning
Evening
r-Retinoate™ Day & Night
Full Size (0)
Step 3: Moisturize
r-Retinoate™ Ultimate Night
Evening
r-Retinoate™ Ultimate Night
Full Size (0)
Step 4: Eye
Morning
Evening
()
Key Ingredients
Encapsulated Retinyl Retinoate

Patented and exclusive to Medik8, this unique retinoid molecule is the breakthrough result of 8 years of expert research. Retinyl retinoate is proven to be 8x more powerful than classic retinol* in delivering astonishing age-defying results.

*H. Kim et al., Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative, Bioorganic & Medicinal Chemistry, 2008, 15;16(12), pp 6387-93

Encapsulated Retinal

This next-generation retinoid works to target the look of fine lines, wrinkles, dark spots and uneven skin texture - 11x faster than standard retinol.* Its unique antibacterial properties also help to visibly decongest the skin.

*G. Siegenthaler et al., Retinol and retinal metabolism, Biochemical Journal, 1990, 268, pp 371-378

Drone-Targeted Peptide

A youth-boosting copper peptide, encapsulated in an innovative polymer shell which allows it to act where it's needed most for maximum visible effect.

Ceramide Complex

A unique combination of ceramides and other skin-identical lipids which help to replenish your skin's natural lipid barrier and deeply nourish skin.

Drone-Targeted Peptide

A youth-boosting copper peptide, encapsulated in an innovative polymer shell which allows it to act where it's needed most for maximum visible effect.

Ceramide Complex

A unique combination of ceramides and other skin-identical lipids which help to replenish your skin's natural lipid barrier and deeply nourish skin.

Full List of Ingredients
r-Retinoate™ Ultimate Night
Youth Awakening Cream

Water, Caprylic/Capric Triglyceride, Glycerin, Butylene Glycol, Isododecane, Squalane, Cetearyl Alcohol, Dimethicone, Cetearyl Olivate, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Polylactic Acid, Cyclodextrin, PPG-12/SMDI Copolymer, Sorbitan Olivate, Sodium Hyaluronate, Tocopheryl Acetate, Rubus Chamaemorus Seed Oil, Canola Oil, Pentylene Glycol, Citric Acid, Alumina, Phenoxyethanol, Isostearic Acid, Lecithin, Polyglyceryl-3 Polyricinoleate, Polyhydroxystearic Acid, Stearic Acid, Sodium Lauroyl Lactylate, Vanilla Planifolia Fruit Extract, Ceramide NP, Daucus Carota Sativa Seed Oil, Retinal, Retinyl Retinoate, 3-O-Ethyl Ascorbic Acid, Sodium Polyaspartate, Ceramide AP, Phytosphingosine, Disodium EDTA, Phytosterols, Copper Palmitoyl Heptapeptide-14, Heptapeptide-15 Palmitate, Ceramide EOP, Phenethyl Alcohol, Cholesterol, Lonicera Japonica (Honeysuckle) Flower Extract, Lonicera Caprifolium (Honeysuckle) Flower Extract, C12-16 Alcohols, BHT, Caprylyl Glycol, Carbomer, Linoleic Acid, Palmitic Acid, Xanthan Gum, Cholesteryl Nonanoate, Ethylhexylglycerin, Hydrogenated Lecithin, Glyceryl Caprylate, Lactic Acid/Glycolic Acid Copolymer, Polyvinyl Alcohol, Phenylpropanol, Fragrance*, Limonene, Linalool, Citral, Red 4, Titanium Dioxide/CI 77891. *natural extracts

*Although we try our best to ensure this list of ingredients is accurate there may be product upgrades from time to time, or slight variants between different regions based on local laws, meaning the only definitive ingredient list is that which is printed on the product packaging.
  • Clinically proven formula
  • No artifical fragrance
  • No synthetic colors
  • Paraben free
Experts Recommended

The most powerful age-defying formula we have ever made.

DANIEL ISAACS
Chief Product Officer

r-Retinoate Intense is amazing!

KATHERINE PATERSON
Aesthetician

The only vitamin A that has improved my skin without irritation.

CAROLINE BARNES
Makeup Artist

Complete Your Regime

Reviews

Frequently Asked Questions

Can I use r-Retinoate™ Ultimate Night if I'm pregnant or breastfeeding?
As a cosmetics company, we are unable to provide product advice in relation to medical conditions such as pregnancy or breastfeeding. We strongly recommend discussing the ingredients with your physician or obstetrician before use. We do, however, generally recommend avoiding vitamin A use while pregnant or breastfeeding, which is why we offer a plant-based vitamin A alternative - Bakuchiol Peptides.
How and when should I apply r-Retinoate™ Ultimate Night?
r-Retinoate™ Ultimate Night should be applied in the evening. After cleansing, massage 2 pumps evenly across the face, neck and décolletage.
At what age can I start to use this product?
All of our products are suitable for those aged 16+ - including r-Retinoate™ Ultimate Night.
Is r-Retinoate™ Intense the same as r-Retinoate™ Ultimate Night?
Yes. The formulas are exactly the same. They simply have different names for our European and US markets.
Do I need to use a moisturizer on top of r-Retinoate™ Ultimate Night?
No. r-Retinoate™ Ultimate Night is carefully formulated to be an all-in-one product for your nighttime routine. Boosted with hydrating hyaluronic acid and nourishing ceramides, it contains all of the moisturizing actives your skin needs in the evening.
What’s the difference between r-Retinoate™ Day & Night and r-Retinoate™ Ultimate Night?
r-Retinoate™ Day & Night is formulated with retinyl retinoate, a unique form of vitamin A that’s photostable (meaning it doesn’t lose its power when exposed to sunlight). This means it’s a vitamin A formula that can be used both morning and night for accelerated age-defying results. r-Retinoate™ Ultimate Night is a 5-in-1 night cream and the jewel in the Medik8 vitamin A crown. Combining 5 of Medik8's most advanced age-defying technologies in 1 extraordinary nighttime cream (retinyl retinoate, retinal, ceramides, peptides and hyaluronic acid), it delivers everything your skin needs for astonishing youth-renewing results in one simple but luxurious step. Remember; r-Retinoate™ Ultimate Night can only be used in the evening due to it containing retinal (which is not photostable).
Do I need to use a moisturizer on top of r-Retinoate™ Ultimate Night?
No. r-Retinoate™ Ultimate Night is carefully formulated to be an all-in-one product for your nighttime routine. Boosted with hydrating hyaluronic acid and nourishing ceramides, it contains all of the moisturizing actives your skin needs in the evening.
What’s the difference between r-Retinoate™ Day & Night and r-Retinoate™ Ultimate Night?
r-Retinoate™ Day & Night is formulated with retinyl retinoate, a unique form of vitamin A that’s photostable (meaning it doesn’t lose its power when exposed to sunlight). This means it’s a vitamin A formula that can be used both morning and night for accelerated age-defying results. r-Retinoate™ Ultimate Night is a 5-in-1 night cream and the jewel in the Medik8 vitamin A crown. Combining 5 of Medik8's most advanced age-defying technologies in 1 extraordinary nighttime cream (retinyl retinoate, retinal, ceramides, peptides and hyaluronic acid), it delivers everything your skin needs for astonishing youth-renewing results in one simple but luxurious step. Remember; r-Retinoate™ Ultimate Night can only be used in the evening due to it containing retinal (which is not photostable).
r-Retinoate™ Ultimate Night
Full Size
Full Size